Diterpenoids from  Euphorbia neriifolia  and Their Related Anti‐HIV and Cytotoxic Activity | Zendy

Li JianChun | Zendy; Feng XiaoYi | Zendy; Liu Dan | Zendy; Zhang ZhiJun | Zendy; Chen XuanQin | Zendy; Li RongTao | Zendy; Li HongMei | Zendy

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Diterpenoids from Euphorbia neriifolia and Their Related Anti‐HIV and Cytotoxic Activity

Author(s) -

Li JianChun,

Feng XiaoYi,

Liu Dan,

Zhang ZhiJun,

Chen XuanQin,

Li RongTao,

Li HongMei

Publication year - 2019

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.201900495

Subject(s) - chemistry , cytotoxic t cell , human immunodeficiency virus (hiv) , traditional medicine , virology , biochemistry , in vitro , biology , medicine

Fifteen diterpenoids ( 1 – 15 ), including three undescribed ones with ent ‐atisane skeleton, eupnerias G–I ( 1 – 3 ), were obtained from Euphorbia neriifolia . Compounds 1 – 3 were established through comprehensive spectroscopic analysis. Compounds 4 and 5 exhibited obvious anti‐HIV‐1 effect, and their EC 50 were 6.6±3.2 and 6.4±2.5 μg mL −1 , respectively. Compound 6 exhibited moderate cytotoxicity on HepG2 and HepG2/Adr cells with IC 50 at 13.70 and 15.57 μ m , respectively. In addition, compound 15 exhibited significant cytotoxicity on HepG2 cell lines (IC 50 =0.01 μ m ), while it did not show any cytotoxicity against HepG2/Adr cell lines.

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