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Two New Isomeric Andrographolides with Anti‐Inflammatory and Cytotoxic Activity
Author(s) -
Liu Difa,
Wang Zhangwei,
Liu Yaoqi,
Zhang Yi,
Guo Eryan,
He Mingzhen,
Liu Junshan,
Deng Shuangbing,
Ye Wencai,
Xie Ning
Publication year - 2020
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201900494
Subject(s) - chemistry , andrographolide , cytotoxic t cell , quantum chemical , stereochemistry , organic chemistry , in vitro , biochemistry , molecule
Abstract Two novel epimerized andrographolides, 8,17‐dihydro‐7,8‐dehydroandrographolide and 10 β ‐8,17‐dihydro‐7,8‐dehydroandrographolide, were isolated from andrographolide sulfonates. Their structures were elucidated by detailed NMR analysis, single‐crystal X‐ray diffraction and quantum chemical ECD calculations. In addition, these compounds exhibited suppression of NO production in LPS‐stimulated RAW264.7 cells over the range of 1.564 to 25.000 μg/mL.