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Novel Metabolites from the Endophytic Fungus Chaetomium subaffine L01
Author(s) -
Han XiaoYang,
Xie YiXuan,
Wu ChaoQun,
Ai HongLian,
Lei XinXiang,
Wang XiangJing
Publication year - 2019
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201900471
Subject(s) - chemistry , chaetomium , polyene , stereochemistry , fungus , circular dichroism , glycoside , cytotoxicity , absolute configuration , biochemistry , botany , food science , in vitro , biology , penicillium
One natural p ‐terphenyl glycoside, gliocladinin C, and two furano‐polyene derivatives, chaetominins A and B, were isolated from potato endophytic fungus Chaetomium subaffine . The absolute configurations of these compounds were elucidated by HR‐ESI‐MS, NMR, the DP4+ probabilities and electronic circular dichroism (ECD) spectra. Furthermore, gliocladinin C and chaetominin A showed cytotoxic activity against two selected human tumor cell lines (Hep‐2 and HepG‐2).