Novel Metabolites from the Endophytic Fungus  Chaetomium subaffine  L01 | Zendy

Han XiaoYang | Zendy; Xie YiXuan | Zendy; Wu ChaoQun | Zendy; Ai HongLian | Zendy; Lei XinXiang | Zendy; Wang XiangJing | Zendy

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Novel Metabolites from the Endophytic Fungus Chaetomium subaffine L01

Author(s) -

Han XiaoYang,

Xie YiXuan,

Wu ChaoQun,

Ai HongLian,

Lei XinXiang,

Wang XiangJing

Publication year - 2019

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.201900471

Subject(s) - chemistry , chaetomium , polyene , stereochemistry , fungus , circular dichroism , glycoside , cytotoxicity , absolute configuration , biochemistry , botany , food science , in vitro , biology , penicillium

One natural p ‐terphenyl glycoside, gliocladinin C, and two furano‐polyene derivatives, chaetominins A and B, were isolated from potato endophytic fungus Chaetomium subaffine . The absolute configurations of these compounds were elucidated by HR‐ESI‐MS, NMR, the DP4+ probabilities and electronic circular dichroism (ECD) spectra. Furthermore, gliocladinin C and chaetominin A showed cytotoxic activity against two selected human tumor cell lines (Hep‐2 and HepG‐2).

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