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Front Cover: Graphostromols A–K, Eleven New Chained Polyketides from the Deep‐Sea‐Derived Graphostroma sp (C&B 9/2019)
Author(s) -
Niu Siwen,
Xie ChunLan,
Xia JinMei,
Zhong Tianhua,
Luo Zhuhua,
Shao Zongze,
Yang XianWen
Publication year - 2019
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201900448
Subject(s) - hela , deep sea , front cover , cover (algebra) , hydrothermal circulation , sulfide , fungus , microorganism , chemistry , hydrothermal vent , deep sequencing , oceanography , geology , gene , paleontology , bacteria , cell , biochemistry , organic chemistry , mechanical engineering , engineering , genome
Front Cover . With the advancement in submersible technology, more and more marine microorganisms have been isolated from deep‐sea environments. However, as the most extreme and dynamic environments of the world, the deep‐sea hydrothermal vents are still poorly investigated. Graphostroma sp. MCCC 3 A00421 was isolated from hydrothermal sulfide deposits of the Atlantic Ocean at the depth of −2721 m. Chromatographic separation on the crude extract of this fungus resulted in the isolation of eleven new chained polyketides, namely graphostromols A − K ( 1 − 11 ). However, none of them showed cytotoxic effects against five different cancer cell lines of HeLa, Eca‐109, Biu‐87, Bel‐7402, and PANC‐1. Graphostromols A − E ( 1 − 5 ), bearing a 2,2,10,10‐tetramethyldodecane skeleton, were discovered for the first time from nature, as reported by Yang et al . in their full paper at 10.1002/cbdv.201900326.