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Chemodiversity and Antiproliferative Activity of the Essential Oil of Schinus molle Growing in Jordan
Author(s) -
Aboalhaija Nour H.,
Awwad Oriana,
Khalil Enam,
Abbassi Reem,
Abaza Ismail F.,
Afifi Fatma U.
Publication year - 2019
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201900388
Subject(s) - chemistry , essential oil , gas chromatography–mass spectrometry , food science , composition (language) , extraction (chemistry) , gas chromatography , ethanol , mass spectrometry , traditional medicine , chromatography , biochemistry , medicine , linguistics , philosophy
The leaves and unripe and fully‐grown fruits of Schinus molle were collected from three geographical regions of Jordan: Amman (the Mediterranean), Madaba (Irano‐Turanean), and Sahab (Saharo‐Arabian). The hydrodistilled volatile oils of fresh and dried leaves and fruits were analyzed by gas chromatography‐mass spectrometry (GC/MS). The actual composition of the emitted volatiles was determined using Solid Phase Micro‐Extraction (SPME). α ‐ and β ‐Phellandrenes were the major components in all the analyzed samples. Quantitative differences were observed in the obtained essential oils (0.62–5.25 %). Additionally, cluster analysis was performed. Biologically, the antiproliferative activity of the essential oil, ethanol, and water extracts of the fruits and leaves was screened on Caco2, HCT116, MCF7, and T47D cell lines. The essential oil and ethanol extracts exhibited a dose‐dependent inhibition of cell growth with IC 50 ranging between 21 and 65 μg/mL. The water extract did not exhibit any antiproliferative activity against the investigated cell lines.