Premium
Synthesis and Antibacterial Evaluation of Mannich Bases Derived from 1,2,4‐Triazole
Author(s) -
Paneth Agata,
Trotsko Nazar,
Popiołek Łukasz,
Grzegorczyk Agnieszka,
Krzanowski Tomasz,
Janowska Sara,
Malm Anna,
Wujec Monika
Publication year - 2019
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201900377
Subject(s) - chemistry , bacillus subtilis , antibacterial activity , staphylococcus epidermidis , piperazine , in vitro , staphylococcus aureus , potency , combinatorial chemistry , stereochemistry , mannich base , bacteria , biochemistry , organic chemistry , genetics , biology
The series of novel Mannich bases were synthesized and evaluated for their in vitro antibacterial activity against Gram‐positive and Gram‐negative bacterial strains. The results showed that all compounds were less active than the drugs used as reference, but some of them had moderate potency against Staphylococcus epidermidis ATCC 12228 and Bacillus subtilis ATCC 6633. The presence of a phenyl ring in the position 4 of piperazine seems to be necessary for antibacterial activity in this class of compounds.