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Aureonitols A and B, Two New C 13 ‐Polyketides from Chaetomium globosum , an Endophytic Fungus in Salvia miltiorrhiza
Author(s) -
Yang ShengXiang,
Zhao WenTing,
Chen HengYe,
Zhang Lei,
Liu TingKai,
Chen HePing,
Yang Jian,
Yang XiaoLong
Publication year - 2019
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201900364
Subject(s) - chaetomium globosum , salvia miltiorrhiza , staphylococcus epidermidis , microbiology and biotechnology , enterococcus faecalis , antimicrobial , enterococcus faecium , chemistry , fungus , chaetomium , panax notoginseng , staphylococcus aureus , botany , biology , bacteria , antibiotics , aspergillus , medicine , alternative medicine , genetics , pathology , traditional chinese medicine
Two new C 13 ‐polyketides, aureonitols A and B ( 1 and 2 ), along with five known compounds ( 3 – 7 ), were isolated from the solid fermentation culture of the plant endophytic fungus Chaetomium globosum from the aerial parts of Salvia miltiorrhiza . The structures and absolute configurations of 1 and 2 were determined by comprehensive spectroscopic data analysis and computed methods. Compound 5 was found to display the remarkable antimicrobial activities against four multidrug‐resistant bacteria ( Enterococcus faecalis , Enterococcus faecium , Staphylococcus aureus , and Staphylococcus epidermidis ) with MIC values of 3.13–6.25 μg/mL (ciprofloxacin: 0.78–1.56 μg/mL), and also against all tested fungal strains with MIC values of 3.13–25 μg/mL (ketoconazole: 0.78–12.50 μg/mL).