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In Vitro Trypanocidal and Antibacterial Activities of Essential Oils from Four Species of the Family Annonaceae
Author(s) -
Bay Marcia,
Souza de Oliveira João Vitor,
Sales Junior Policarpo Ademar,
Fonseca Murta Silvane Maria,
Rogério dos Santos Anderson,
Santos Bastos Ivanildes,
Puccinelli Orlandi Patrícia,
Teixeira de Sousa Junior Paulo
Publication year - 2019
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201900359
Subject(s) - annonaceae , antibacterial activity , chemistry , streptococcus mutans , essential oil , traditional medicine , minimum inhibitory concentration , microbiology and biotechnology , antimicrobial , biology , botany , food science , bacteria , medicine , genetics
The objective of this study was to evaluate the chemical composition, and the trypanocidal and antibacterial activities of the essential oils from four species of Annonaceae: Bocageopsis multiflora ( Mart .) R.E. Fr ., Duguetia quitarensis Benth ., Fusaea longifolia ( Aubl. ) Saff ., and Guatteria punctata ( Aubl .) R.A. Howard . The chemical composition of the essential oils from the aerial parts yielded 23, 20, 21 and 23 constituents, respectively, which were identified by GC/MS. The trypanocidal activity was evaluated against the amastigote and trypomastigote forms of T. cruzi . The antibacterial activity was evaluated by the microdilution method against enterohemorrhagic Escherichia coli , Pseudomonas aeruginosa , Streptococcus mutans , Streptococcus pyogenes , and methicillin‐resistant Staphylococcus aureus . The results of trypanocidal activity showed that the essential oils of the four species were active at the tested concentrations, with G. punctata essential oil being the most active, with IC 50 =0.029 μg/mL, and selectivity index (SI)=32, being 34 times more active than the reference drug benznidazole. All EOs showed strong antibacterial activity (minimum inhibitory concentrations of 4.68–37.5 μg/mL) against strains of S. mutans .