Phialomyces macrosporus : Chemical Constituents, Antimicrobial Activity and Complete NMR Assignments for the 7,7′‐Biphyscion | Zendy

Silva Brandão Mauricio | Zendy; Silva Abreu Lucas | Zendy; Geris Regina | Zendy

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Phialomyces macrosporus : Chemical Constituents, Antimicrobial Activity and Complete NMR Assignments for the 7,7′‐Biphyscion

Author(s) -

Silva Brandão Mauricio,

Silva Abreu Lucas,

Geris Regina

Publication year - 2019

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.201900353

Subject(s) - chemistry , antimicrobial , bacillus subtilis , stereochemistry , trehalose , proton nmr , nuclear magnetic resonance spectroscopy , chromatography , biochemistry , organic chemistry , bacteria , genetics , biology

Five known secondary metabolites, chrysophanol ( 1 ), 7,7′‐biphyscion ( 2 ), secalonic acid D ( 3 ), mannitol ( 4 ) and trehalose ( 5 ) were isolated for the first time from the extracts of the fungus Phialomyces macrosporus . Their structures were elucidated by NMR methods (1D and 2D NMR analysis), optical activity and ESI‐MS. Complete 1 H and 13 C assignments were performed for compound 2 . The antimicrobial activity was evaluated by serial microdilution assay for compounds 2 and 3 and results showed that compound 3 exhibited a significant growth inhibition at concentrations of 15.6 mg/ml ( S. aureus and S. choleraesius ) and 0.97 mg/mL ( B. subtilis ), comparable to the positive control.

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