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Comparative Analysis of the Antibacterial Activity and HPLC Phytochemical Screening of the Brazilian Red Propolis and the Resin of Dalbergia ecastaphyllum
Author(s) -
Silveira RegueiraNeto Marcos,
Relison Tintino Saulo,
Pereira da Silva Ana Raquel,
Socorro Costa Maria,
Morais OliveiraTintino Cícera Datiane,
Augusti Boligon Aline,
Menezes Irwin R. A.,
Queiroz Balbino Valdir,
Melo Coutinho Henrique Douglas
Publication year - 2019
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201900344
Subject(s) - propolis , chemistry , antibacterial activity , phytochemical , minimum inhibitory concentration , high performance liquid chromatography , traditional medicine , antibiotics , chromatography , food science , bacteria , biology , biochemistry , medicine , genetics
The aim of this study was to investigate the antibacterial activity of red propolis and resin and their association with standard antibiotics to evaluate possible differences of activity. We also submitted red propolis and the resin to a HPLC analysis to confirm the botanical origin. The extracts were tested against P. aeruginosa and S. aureus alone and in association with gentamicin and imipenem. The HPLC analysis identified seven compounds with six of them present in both substances. The lowest MIC values obtained in this study were observed against S. aureus . In general, MIC values showed to be lower for red propolis against all species tested in comparison to resin. Despite the synergistic behavior to be similar for both substances, we observed that inhibitory concentrations of drugs were lower when associated with red propolis in comparison to resin.