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Phytochemical Content, Antidiabetic, Anticholinergic, and Antioxidant Activities of Endemic Lecokia cretica Extracts
Author(s) -
Aras Abdülmelik,
Bursal Ercan,
Türkan Fikret,
Tohma Hatice,
Kılıç Ömer,
Gülçin İlhami,
Köksal Ekrem
Publication year - 2019
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201900341
Subject(s) - chemistry , quinic acid , antioxidant , dpph , chlorogenic acid , butyrylcholinesterase , phytochemical , malic acid , acetylcholinesterase , traditional medicine , enzyme , food science , aché , biochemistry , citric acid , medicine
The aim of this work was to investigate the enzyme inhibition, antioxidant activity, and phenolic compounds of Lecokia cretica ( Lam .) DC. Acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α ‐glycosidase enzymes were strongly inhibited by the L. cretica extracts. IC 50 values for the three enzymes were found as 3.21 mg/mL, 2.1 mg/mL, and 2.07 mg/mL, respectively. Antioxidant activities were examined in both aqueous and ethanol (EtOH) extracts using CUPRAC, FRAP, and DPPH method. Also, the phenolic compounds of the endemic plant were identified and quantified by using HPLC/MS/MS. According to the results, the extracts have remarkable antioxidant activities. The most abundant phenolic acids of L. cretica in EtOH extract were determined as quinic acid (12.76 mg/kg of crude extract), chlorogenic acid (3.39 mg/kg), and malic acid (2.38 mg/kg).