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Graphostromols A–K, Eleven New Chained Polyketides from the Deep‐Sea‐Derived Graphostroma sp
Author(s) -
Niu Siwen,
Xie ChunLan,
Xia JinMei,
Zhong Tianhua,
Luo Zhuhua,
Shao Zongze,
Yang XianWen
Publication year - 2019
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201900326
Subject(s) - hela , chemistry , fungus , absolute configuration , stereochemistry , fermentation , cancer cell lines , cancer cell , cancer , cell , organic chemistry , biochemistry , botany , biology , genetics
Chromatographic separation of the AcOEt extract of the fermented cultures of the deep‐sea‐derived fungus Graphostroma sp. resulted in the isolation of 11 new chained polyketides, namely graphostromols A – K ( 1–11 ). The structures of the new compounds were established by the extensive analyses of their NMR and HR‐ESI‐MS data. The absolute configuration at C‐11 in 1 was determined on the basis of the modified Mosher's method. Compounds 1–5 , bearing a 2,2,10,10‐tetramethyldodecane skeleton, were discovered for the first time from nature. All isolates were evaluated for their cytotoxicities against five different cancer cell lines (HeLa, Eca‐109, Biu‐87, Bel‐7402, and PANC‐1). However, none showed positive effects.