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Spectroscopic and Structural Characterization, Enzyme Inhibitions, and Antioxidant Effects of New Ru(II) and Ni(II) Complexes of Schiff Base
Author(s) -
Buldurun Kenan,
Turan Nevin,
Aras Abdulmelik,
Mantarcı Asim,
Turkan Fikret,
Bursal Ercan
Publication year - 2019
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201900243
Subject(s) - chemistry , schiff base , antioxidant , enzyme , base (topology) , characterization (materials science) , stereochemistry , medicinal chemistry , polymer chemistry , nuclear chemistry , biochemistry , nanotechnology , mathematical analysis , materials science , mathematics
The new complex compounds [RuLCl( p ‐cymene)] ⋅ 3H 2 O and [NiL 2 (H 2 O) 2 ] ⋅ 3H 2 O (L: 1‐{4‐[(2‐hydroxy‐3‐methoxybenzylidene)amino]phenyl}ethanone) were prepared and characterized using FT‐IR, 1 H‐ and 13 C‐NMR, mass spectroscopy, TGA, elemental analysis, X‐ray powder diffraction and magnetic moment techniques. Octahedral geometry for new Ni(II) and Ru(II) complexes was proposed. Thermal decomposition confirmed the existence of lattice and coordinated water molecule in the complexes. To determine the antioxidant properties of Schiff base ligand and its Ni(II), Ru(II) metal complexes, FRAP, CUPRAC, ABTS and DPPH methods of antioxidant assays were used. Moreover, enzyme inhibition of complexes was evaluated against carbonic anhydrase I and II isoenzymes (CA I and CA II) and acetylcholinesterase (AChE). For CA I and CA II, the best inhibition enzymes, was the Ni(II) complex with 62.98±18.41, 86.17±23.62 Ki values, whereas this inhibition effect showed ligand with 24.53±2.66 Ki value for the AChE enzyme.