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Melanogenesis Inhibitors from the Endophytic Fungus Aspergillus amstelodami
Author(s) -
Elsbaey Marwa,
Sallam Amal,
ElMetwally Mohamed,
Nagata Maki,
Tanaka Chiaki,
Shimizu Kuniyoshi,
Miyamoto Tomofumi
Publication year - 2019
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201900237
Subject(s) - arbutin , chemistry , aspergillus , fungus , stereochemistry , positive control , microbiology and biotechnology , biochemistry , traditional medicine , botany , biology , medicine
Two new compounds, named 3,4‐dimethoxyphenyl α ‐ d ‐ribofuranoside ( 1 ) and 3 β ‐( β ‐ d ‐glucopyranosyloxy)olean‐12‐ene‐23,28,30‐trioic acid ( 2 ), together with thirteen known compounds, were isolated from the white beans culture of the marine derived endophytic fungus Aspergillus amstelodami . Structure elucidation of the new compounds was carried out by one‐, two‐dimensional spectroscopy, and high resolution electrospray ionization mass. The antimelanogenic and anti‐allergic activity of the isolated compounds were investigated. Compounds 4 , 7 , 1 , 3 , 11 , 6 and 9 selectively suppressed melanin production in B16 melanoma cells, using arbutin as a positive control. Their IC 50 values were 30.8±5.57, 38.5±6.08, 52.6±6.64, 98.0±1.16, 100.4±3.05, 112.0±0.22 and 144.7±2.35 μ m , respectively, while that of arbutin was 151.7±1.27 μ m . The tested compounds did not show any significant anti‐allergic activity in RBL‐2H3 cells, as compared to quercetin.