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New 4,5‐ seco ‐20(10→5)‐ abeo ‐Abietane Diterpenoids with Anti‐Inflammatory Activity from Isodon lophanthoides var. graciliflorus ( Benth .) H. Hara
Author(s) -
Chen WenFei,
Wong LaiLai,
Zhang Xuan,
Zhou FengXu,
Xia Fan,
Tang LiPing,
Li Xian
Publication year - 2019
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201900206
Subject(s) - abietane , chemistry , terpenoid , stereochemistry , terpene , diterpene , two dimensional nuclear magnetic resonance spectroscopy
Three new 4,5‐ seco ‐20(10→5)‐ abeo ‐abietane diterpenoids, 16‐hydroxysalvilenone ( 1 ), 15‐hydroxysalprionin ( 2 ), and 11 β ,15‐dihydroxysalprionin‐12‐one ( 3 ), and nine known abietane diterpenoids, 4 – 12 , along with one known sempervirane diterpenoid, hispidanol A ( 13 ), were isolated from the aerial parts of Isodon lophanthoides var. graciliflorus . The structures of compounds 1 – 3 were determined on the basis of spectroscopic methods including extensive analysis of NMR and mass spectroscopic data. All diterpenoids were tested for their TNF‐ α inhibitory effects on LPS‐induced RAW264.7 cells. Compound 9 (16‐acetoxyhorminone) was the most potent with an IC 50 value of 3.97±0.70 μ m .