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Eleven New Triterpenoid Glycosides from the Roots of Ilex asprella
Author(s) -
Huang XiaoJun,
Wen Si,
Guan XiFeng,
Wu ZhenLong,
Li ManMei,
Fan ChunLin,
Zhang QingWen,
Chan Ging,
Wang Ying,
Ye WenCai
Publication year - 2019
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201900202
Subject(s) - glycoside , chemistry , triterpenoid , oleanane , stereochemistry , terpene , nitric oxide , triterpene , organic chemistry , medicine , alternative medicine , pathology
Asprellosides A‐K, nine new ursane‐type triterpenoid glycosides ( 1 – 9 ), and two new oleanane‐type triterpenoid glycosides ( 10 and 11 ), including six rare sulfated triterpenoid glycosides, were isolated from the roots of Ilex asprella . Their structures were determined on the basis of comprehensive spectroscopic analysis and chemical methods. Among these compounds, asprelloside B ( 2 ) and asprelloside C ( 3 ) are the first examples of triterpenoid glycosides bearing a rare 3,4‐ O ‐disulfo‐xylopyranosyl residue. All the saponins isolated showed no significant effects against respiratory syncytial virus (RSV) and lipopolysaccharide‐induced nitric oxide production in Raw264.7 macrophages.