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Stilbene Glycoside Oligomers from the Roots of Polygonum multiflorum
Author(s) -
Li ShuoGuo,
Huang XiaoJun,
Zhong YuanLin,
Li ManMei,
Li YaoLan,
Wang Ying,
Ye WenCai
Publication year - 2019
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201900192
Subject(s) - polygonum , chemistry , circular dichroism , glycoside , quantum chemical , stereochemistry , molecule , organic chemistry , traditional medicine , medicine
Five new trans ‐2,3,5,4′‐tetrahydroxystilbene 2‐ O ‐ β ‐ d ‐glucopyranoside (TSG)‐based stilbene glycoside oligomers ( 1 – 5 ) were isolated from the roots of Polygonum multiflorum . Their structures were elucidated by comprehensive spectroscopic analyses and chemical evidences. The absolute configurations of 1 , 2 , 4 , and 5 were established by quantum‐chemical electronic circular dichroism (ECD) calculations. Putative biosynthetic pathways of 1–5 were proposed using TSG as the key precursor. In addition, compounds 1 (multiflorumiside H) and 3 (multiflorumiside J) exhibited moderate inhibitory activities against NO production in LPS‐stimulated RAW264.7 cells.