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Sesquiterpenoid Compounds from Curcuma kwangsiensis
Author(s) -
Liao HaiBing,
Feng WuYing,
Wang HengShan,
Liang Dong
Publication year - 2019
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201900123
Subject(s) - rhizome , chemistry , nitric oxide , curcuma , in vitro , lipopolysaccharide , stereochemistry , traditional medicine , ic50 , terpene , two dimensional nuclear magnetic resonance spectroscopy , biochemistry , organic chemistry , biology , immunology , medicine
Two previously undescribed guaiane‐type sesquiterpenes ( 1 and 2 ), a pair of new salvialane‐type sesquiterpenes ( 3a and 3b ), together with 11 known compounds were isolated and purified from the rhizomes of Curcuma kwangsiensis . Their structures were elucidated by the extensive spectroscopic data (1D‐ and 2D‐NMR) analysis. All the isolated compounds were assessed for their anti‐neuroinflammatory activity by inhibiting the nitric oxide (NO) production in lipopolysaccharide (LPS)‐activated murine BV‐2 microglial cells in vitro assay, and the isolates 3 and 11 showed anti‐neuroinflammatory activity with IC 50 values of 1.85 and 20.05 μ m , respectively.