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New Immunomodulating Polyhydroxypregnane Glycosides from the Roots of Cynanchum otophyllum C.K. Schneid .
Author(s) -
Zhan ZhaJun,
Bao ShuMin,
Zhang Yue,
Qiu FeiJun,
Shan WeiGuang,
Ma LieFeng
Publication year - 2019
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201900062
Subject(s) - chemistry , splenocyte , glycoside , in vitro , hydrolysis , immune system , acid hydrolysis , stereochemistry , traditional medicine , biochemistry , biology , immunology , medicine
Seven new polyhydroxypregnane glycosides, named cynotophyllosides P–V, together with three known analogs were isolated from the roots of Cynanchum otophyllum C.K. Schneid . Their structures were elucidated by a variety of spectroscopic techniques, as well as acid‐catalyzed hydrolysis. All isolates were tested for their immunological activities in vitro against Con A‐ and LPS‐induced proliferation of mice splenocytes. Immunoenhancing (for 1 , 9 ) and immunosuppressive (for 2 ) activities were observed. Furthermore, cynotophylloside R ( 3 ) showed immunomodulatory as it enhanced the proliferation of splenocytes in low concentration and suppressed immune cells in concentration more than 1.0 μg/ml.
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