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Sesquiterpenes from the Leaves of Magnolia delavayi Franch . and Their Cytotoxic Activities
Author(s) -
Xie ZhangQiao,
Ding LinFen,
Wang DeSheng,
Nie Wei,
Liu JiangXin,
Qin Jing,
Song LiuDong,
Wu XingDe,
Zhao QinShi
Publication year - 2019
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201900013
Subject(s) - chemistry , cytotoxic t cell , in vitro , stereochemistry , cancer cell lines , magnoliaceae , traditional medicine , cancer cell , botany , biochemistry , cancer , biology , medicine , genetics
Thirteen sesquiterpenes including eight new ones, magnodelavins A−H ( 1 – 8 ), were obtained from the 95 % ethanolic extract of the leaves of Magnolia delavayi Franch . The structures of the new compounds were determined by exhaustive 1 H‐, 13 C‐, 2D‐NMR, UV, IR, and HR‐ESI‐MS data, as well as X‐ray crystallographic analysis. Compounds 9 and 10 showed potent cytotoxic activities against HL‐60, A‐549, SMMC‐7721, MCF‐7, and SW480 human cancer cell lines in vitro using MTS assay.