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Structural Characterization and Biological Evaluation of 18‐Nor‐ ent ‐labdane Diterpenoids from Grazielia gaudichaudeana
Author(s) -
Balbinot Rodolfo B.,
de Oliveira Josiane A. M.,
Bernardi Darlon I.,
Melo Ulisses Z.,
Zanqueta Érica B.,
Endo Eliana H.,
Ribeiro Fabianne M.,
Volpato Hélito,
Figueiredo Mariana C.,
Back Davi F.,
Basso Ernani A.,
Ruiz Ana L. T. G.,
de Carvalho João E.,
Foglio Mary Ann,
Prado Filho Benedito D.,
Nakamura Tania U.,
Nakamura Celso V.,
do Carmo Marta R. B.,
Sarragiotto Maria H.,
Baldoqui Debora C.
Publication year - 2019
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800644
Subject(s) - labdane , chemistry , characterization (materials science) , stereochemistry , diterpene , traditional medicine , nanotechnology , medicine , materials science
The phytochemical investigation of Grazielia gaudichaudeana aerial parts yielded 15 compounds, including diterpenes, triterpenes, sterols and flavonoids. With exception to ent ‐kaurenoic acid diterpenes, the compounds isolated are being described for the first time in this species. Some unusual 1 H‐NMR chemical shifts of 18‐nor‐ ent ‐labdane ( 7 – 9 ) led us carry out a conformational analysis by theoretical calculations in order to support the experimental data. Moreover, due to the limitation of studies focused on pharmacological potential of Grazielia gaudichaudeana , the present study was carried out to investigate the antioxidant, antiproliferative, antiviral, antileishmanial and antimicrobial activities from the extract, fractions and isolated compounds obtained from this species. Ethyl acetate fraction showed significant activity in the antiproliferative assay, with GI 50 range of 3.9 to 27.2 μg mL −1 . Dichloromethane fraction, rich in diterpenoids, inhibited all human tumor cell lines tested, and the nor‐labdane 7 showed potent cytotoxic activity against glioma and ovary cancer cell lines.