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Novel Aminomethyl Derivatives of 4‐Methyl‐2‐prenylphenol: Synthesis and Antioxidant Properties
Author(s) -
Buravlev Evgeny V.,
Fedorova Irina V.,
Shevchenko Oksana G.,
Kutchin Aleksandr V.
Publication year - 2019
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800637
Subject(s) - chemistry , hemolysis , antioxidant , alcohol , mannich base , mannich reaction , catalysis , in vitro , organic chemistry , chelation , stereochemistry , combinatorial chemistry , biochemistry , immunology , biology
4‐Methyl‐2‐prenylphenol ( 1 ) was synthesized from para ‐cresol and prenol, natural alcohol under the conditions of heterogeneous catalysis. A series of nine new aminomethyl derivatives with secondary and tertiary amino groups were obtained on the basis of compound 1 . A comparative evaluation of their antioxidant properties was carried out using in vitro models. It was established that Mannich base with octylaminomethyl group has radical‐scavenging activity, high Fe 2+ ‐chelation ability as well as the ability to inhibit oxidative hemolysis of red blood cells.