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Biological Investigations and Spectroscopic Studies of New Moxifloxacin/Glycine‐Metal Complexes.
Author(s) -
Elshafie Hazem S.,
Sakr Shimaa H.,
Sadeek Sadeek A.,
Camele Ippolito
Publication year - 2019
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800633
Subject(s) - chemistry , metal , chelation , antimicrobial , moxifloxacin , nuclear chemistry , glycine , metal ions in aqueous solution , ligand (biochemistry) , medicinal chemistry , stereochemistry , organic chemistry , biochemistry , receptor , antibiotics , amino acid
Two novel ligand−metal complexes were prepared through the reaction of Zn(II) and Sn(II) with moxifloxacin (MOX) in the presence of glycine (Gly) to investigate their biological activities. IR, UV/VIS and 1 H‐NMR analysis have been carried out for insuring the chelation process. Results suggested that MOX and Gly react with the metal ions through the carbonyl oxygen atom and the oxygen atom of the carboxylic group of MOX and Gly. The antimicrobial activity was carried out against some common bacterial and fungal pathogens and the radical scavenging activity (RSA%) was evaluated using DPPH and ABTS methods. Phytotoxic effect of the prepared complexes was evaluated in vitro against Raphanus raphanistrum and Lepidium sativum . Hemolytic activity was tested against cell membrane of erythrocytes. Results showed that the two prepared complexes exhibited high antimicrobial activity against all tested phytopathogens and no significant phytotoxic effect has been observed. Only MOX−Zn(II) complex showed moderate hemolysis at 100 % concentration.