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A New Aromatic Amide from the Roots of Zanthoxylum tessmannii (Rutaceae)
Author(s) -
Kenmoe Djeukeu Charlie,
Kouam Kenmogne Ariane,
Guy Blaise Azebaze Anatole,
Belle Ebanda Kedi Philippe,
Vardamides Juliette Catherine,
Sewald Norbert,
Duplex Wansi Jean
Publication year - 2019
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800590
Subject(s) - chemistry , rutaceae , lupeol , zanthoxylum , stigmasterol , phytochemical , dpph , ascorbic acid , amide , ether , organic chemistry , stereochemistry , traditional medicine , antioxidant , chromatography , botany , biochemistry , food science , medicine , biology
Phytochemical investigation of the methanolic extract of the roots of Zanthoxylum tessmannii Zepernick and Timler (Rutaceae) led to the isolation and characterization of one new aromatic amide named tessmamide ( 1 ) along with twelve known compounds, N ‐benzoyltyramine methyl ether ( 2 ), 7,8,9‐trimethoxycoumarin ( 3 ), 7,8‐dimethoxycoumarin ( 4 ), integrifoliodiol ( 5 ), robustin ( 6 ), skimmianine ( 7 ), lupeol ( 8 ), lupenone ( 9 ), a mixture of stigmasterol and β ‐sitosterol, and a mixture of their glucosides. The structures of all compounds were determined by comprehensive spectroscopic analyses (1D‐ and 2D‐NMR, EI‐MS, and ESI‐MS) and comparison with known analogs. The determination of the radical scavenging activity using the 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) assay gave moderate antioxidant values for the crude extracts of the roots of Zanthoxylum tessmannii (IC 50 0.8 mg/mL), tessmamide ( 1 ; IC 50 31.8 μ m ), and 7,8,9‐trimethoxycoumarin ( 3 ; IC 50 29.3 μ m ), compared to the standard ascorbic acid (IC 50 11.6 μ m ).