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Iridoid Derivatives with Cytotoxic Activity from Pedicularis uliginosa Bunge
Author(s) -
Liu LiFang,
Yao MingJun,
Li ManYu,
Wu XiaoZhen,
Yuan ChengShan
Publication year - 2019
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800524
Subject(s) - chemistry , iridoid , cytotoxic t cell , stereochemistry , botany , traditional medicine , biochemistry , glycoside , biology , in vitro , medicine
Three new iridoids, rel‐ (4a R ,7 S ,7a S )‐7‐hydroxy‐7‐methyl‐1,4a,5,6,7,7a‐hexahydrocyclopenta[ c ]pyran‐4‐carbaldehyde ( 1 ), 1‐methoxy‐7‐methyl‐1,3,5,6‐tetrahydrocyclopenta[ c ]pyran‐4‐carbaldehyde ( 2 ), and rel‐ (1 R ,4 S ,4a S ,7 R ,7a R )‐7‐methylhexahydro‐1,4‐(epoxymethano)cyclopenta[ c ]pyran‐3(1 H )‐one ( 3 ), together with seven known analogues, were isolated from the 95 % EtOH extract of the whole plants of Pedicularis uliginosa Bunge . Their structures were elucidated via extensive NMR spectroscopy and mass spectral data. In terms of inhibitory effects on human tumor cells, compounds 1 , 2 , 6 , 7 , and 8 exhibited better inhibitory activities against ACHN cells than the positive control (vinblastine).