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Design, Microwave‐Assisted Synthesis and in Vitro Antibacterial and Antifungal Activity of 2,5‐Disubstituted Benzimidazole
Author(s) -
Shi Yanpeng,
Jiang Kai,
Zheng Ran,
Fu Jiaxu,
Yan Liuqing,
Gu Qiang,
Zhang Yumin,
Lin Feng
Publication year - 2019
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800510
Subject(s) - benzimidazole , antifungal , chemistry , antibacterial activity , substituent , in vitro , broad spectrum , combinatorial chemistry , stereochemistry , organic chemistry , microbiology and biotechnology , biochemistry , bacteria , biology , genetics
Abstract Seventeen novel 2,5‐disubstituted benzimidazole derivatives were designed, synthesized and evaluated for their antibacterial activities. The tested compounds B1 – B4 and C2 – C6 exhibited not only good antifungal activity but also favorable broad‐spectrum antibacterial activity. Also, the lowest MIC of antibacterial and antifungal activity was 2 μg/mL and 4 μg/mL, respectively. It suggested that the structure of compound including the different substituent and its sites directly affected the efficacy of the synthesized compounds.