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Chemical Constituents from Tabernaemontana bufalina Lour.
Author(s) -
Xu Jian,
Qu Wei,
Cao WenYuan,
Wang Yue,
Zheng KaiJun,
Luo ShiZheng,
Wu MengYuan,
Liu WenYuan,
Feng Feng,
Zhang Jie
Publication year - 2019
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800491
Subject(s) - chemistry , circular dichroism , alkaloid , stereochemistry , absolute configuration , apocynaceae , cytotoxic t cell , indole alkaloid , cancer cell lines , two dimensional nuclear magnetic resonance spectroscopy , cytotoxicity , chemical structure , ic50 , cancer cell , organic chemistry , traditional medicine , cancer , in vitro , biochemistry , medicine
Investigation of the branches and leaves of Tabernaemontana bufalina Lour . led to afford an undescribed monoterpenoid indole alkaloid, namely (3 R ,7 S ,14 R ,19 S ,20 R )‐19‐hydroxypseudovincadifformine ( 1 ), and nine known metabolites ( 2 – 10 ). Their structures were determined by analysis of their NMR and ESI‐MS spectra, and modified Mosher's and calculated electronic circular dichroism (ECD) methods were used for establishing the absolute configuration of compound 1 . Their cytotoxic activities were assayed using two cancer cell lines. As the results, cytotoxic activities on MDA‐MB‐231 and B16 cells showed IC 50 values of 8.9 and 0.13 μ m for 6 , and of 20.3 and 11.7 μ m for 9 , respectively.