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Antimicrobial Homoisoflavonoids from the Rhizomes of Polygonatum verticillatum
Author(s) -
Sharma Shruti,
Patial Vijeta,
Singh Dharam,
Sharma Upendra,
Kumar Dinesh
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800430
Subject(s) - rhizome , antimicrobial , chemistry , traditional medicine , stereochemistry , organic chemistry , medicine
Three homoisoflavonoids, including a new compound, 5,7‐dihydroxy‐3‐(4‐methoxybenzyl)‐8‐methyl chroman‐4‐one ( 1 ), together with two known compounds, 5,7‐dihydroxy‐3‐(2‐hydroxy‐4‐methoxybenzyl)‐8‐methylchroman‐4‐one ( 2 ) and 5,7‐dihydroxy‐3‐(2‐hydroxy‐4‐methoxybenzyl)‐chroman‐4‐one ( 3 ), were isolated from the rhizomes of Polygonatum verticillatum (L.) All. ( P. verticillatum ). Isolated compounds were characterized on the basis of UV, FT‐IR, ESI‐MS, and 1D‐, 2D‐NMR data. Further, different extract fractions and pure compounds from Polygonatum verticillatum were screened for their antimicrobial potential. Among three pure compounds, compound 2 was found most potent with good zone of microbial growth inhibition as compared to the standards.