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Polyketide and Prenylxanthone Derivatives from the Endophytic Fungus Aspergillus sp. TJ23
Author(s) -
Qiao Yuben,
Tu Kun,
Feng Wenya,
Liu Junjun,
Xu Qianqian,
Tao Li,
Zhu Hucheng,
Chen Chunmei,
Wang Jianping,
Xue Yongbo,
Zhang Yonghui
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800395
Subject(s) - chemistry , ergosterol , stereochemistry , polyketide , circular dichroism , fungus , aspergillus , strain (injury) , cancer cell lines , two dimensional nuclear magnetic resonance spectroscopy , derivative (finance) , ic50 , in vitro , microbiology and biotechnology , cancer cell , biochemistry , botany , biosynthesis , enzyme , cancer , biology , genetics , anatomy , financial economics , economics
Eight secondary metabolites, including a new polyketide, named asperetide ( 1 ) and a new prenylxanthone derivative, called asperanthone ( 4 ), and six known compounds, ( S )‐3‐butyl‐7‐methoxyphthalide ( 2 ), ruguloxanthone C ( 3 ), tajixanthone hydrate ( 5 ), tajixanthone methanoate ( 6 ), salimyxin B ( 7 ), and ergosterol ( 8 ), were isolated and identified from the medicinal plant‐derived fungus, Aspergillus sp. TJ23. The new structures and their absolute configurations were elucidated via multiple methods, including 1D‐ and 2D‐NMR, HR‐ESI‐MS, UV, IR, and the electronic circular dichroism (ECD) calculations. All of the isolates were characterized from the strain for the first time. The in vitro bioassay showed that compounds 3–5 and 8 exerted inhibitory activities against five cancer cell lines (B16, MDA‐MB‐231, 4T1, HepG2, and LLC) with IC 50 values ranging from 5.13 to 36.8 μ m .