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Effect of Costus spiralis ( Jacq .) Roscoe Leaves, Methanolic Extract and Guaijaverin on Blood Glucose and Lipid Levels in a Type II Diabetic Rat Model
Author(s) -
Duarte Regiane C.,
TalebContini Silvia H.,
Pereira Paulo S.,
Oliveira Camila F.,
Miranda Carlos Eduardo S.,
Bertoni Bianca W.,
Coppede Juliana S.,
Willrich Guilherme B.,
Crevelin Eduardo J.,
França Suzelei C.,
Pereira Ana Maria S.
Publication year - 2019
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800365
Subject(s) - chemistry , antioxidant , lipid peroxidation , total cholesterol , food science , aspartate transaminase , streptozotocin , biochemistry , diabetes mellitus , cholesterol , endocrinology , biology , enzyme , alkaline phosphatase
This study aimed to isolate and identify flavonoids with hypoglycemic activity in Costus spiralis leaves. The methanolic extract (ME) was rich in flavonoids, while the powdered leaves (PL) contained considerable amounts of macro‐ and microelements. Oral acute treatment of streptozotocin (STZ)‐induced diabetic rats for 18 h with the C. spiralis PL, ME and isolated guaijaverin (GUA) lowered glycemia, improved oral glucose tolerance and inhibited liver lipid peroxidation. GUA and ME lowered plasma levels of low‐density and non‐high density lipoproteins; GUA also lowered total cholesterol levels. PL, ME and GUA did not significantly alter the plasma levels of triglycerides, high‐density lipoproteins, very low‐density lipoproteins, creatinine and aspartate transaminase, and the total protein levels in the kidney and liver tissues. Therefore, C. spiralis leaves are promising raw materials and rich sources of bioactive flavonoids for the development of novel antidiabetic drugs due to their hypoglycemic, antidyslipidemic and antioxidant actions.