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Albocycline‐type Macrolides with Antibacterial Activities from Streptomyces sp. 4205
Author(s) -
Gu ChengZhen,
Yuan ShengHao,
Lü Jing,
Qiao YiJun,
Song YuanYuan,
Abdalla Elzaki Mohammed Esmail,
Yang ChongRen,
Zhang YingJun,
Zeng RenSen
Publication year - 2019
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800344
Subject(s) - antimicrobial , streptomyces , chemistry , antibiotics , antibacterial activity , microbiology and biotechnology , bacteria , traditional medicine , stereochemistry , biology , biochemistry , organic chemistry , medicine , genetics
The actinomycete genus Streptomyces is characterized by producing bioactive secondary metabolites, including antibiotics. In this study, chemical and biological investigations were carried out on Streptomyces strain 4205 isolated from the paddy soil, leading to the identification and characterization of 10 albocycline‐type macrolides, among which 4 compounds were new, namely albocyclines A–D ( 1 – 4 ). The structures of 1 – 10 were identified according to the 1D‐ and 2D‐NMR spectroscopic data. Furthermore, compounds 1 – 10 were evaluated for antimicrobial activity. Compounds 5 – 7 displayed antimicrobial activities against Candidaalbicans ATCC 90028 with the same MIC value of 10.0 mg/mL and the IC 50 values of 1.5, 1.0, and 1.0 mg/mL, respectively. Thus, the research on Streptomyces sp. is of vital significance for developing new antibiotic agents.