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Anti‐Inflammatory Activities and Related Mechanism of Polysaccharides Isolated from Sargentodoxa cuneata
Author(s) -
Guo Lanfang,
Ma Ruili,
Sun Huifang,
Raza Aun,
Tang Jian,
Li Zhengrong
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800343
Subject(s) - chemistry , nitric oxide , carrageenan , malondialdehyde , superoxide dismutase , in vivo , polysaccharide , pharmacology , anti inflammatory , arthritis , nitric oxide synthase , decoction , in vitro , biochemistry , traditional medicine , oxidative stress , immunology , biology , medicine , microbiology and biotechnology , organic chemistry
Sargentodoxa cuneata decoction has been used to treat arthritis in China for hundreds of years. Herein, the polysaccharide fraction (PSC) purified from S. cuneata was evaluated for its in vitro and in vivo anti‐inflammatory effects. PSC and its sub‐fractions PSCA‐1 and PSCB‐1 significantly suppressed nitric oxide (NO) release in LPS‐induced RAW264.7 cells by down regulating the inducible nitric oxide synthase (iNOS) level. Furthermore, PSC markedly inhibited carrageenan induced rat hind paw edema, decreased in hind paw, serum and liver malondialdehyde (MDA) levels and prostaglandin E 2 (PGE 2 ) levels. In addition, PSC increased superoxide dismutase (SOD) activity in serum and liver of the rats. These results revealed that the polysaccharide obtained from S. cuneata (PSC) possessed potent anti‐inflammatory activity and may be one of the important bioactive constituents from the plant responsible for the anti‐arthritis effect.