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Biological Evaluation of a New Lignan from the Roots of Rice ( Oryza sativa )
Author(s) -
Lee Tae Kyoung,
Lee Dahae,
Yu Jae Sik,
Jo Mun Seok,
Baek Su Cheol,
Shin MyoungSook,
Ko YoonJoo,
Kang Ki Sung,
Kim Ki Hyun
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800333
Subject(s) - oryza sativa , lignan , chemistry , phytochemical , population , cytotoxicity , biochemistry , in vitro , stereochemistry , medicine , gene , environmental health
Abstract LC/MS‐based phytochemical analysis of an EtOH extract of the roots of rice ( Oryza sativa ; Gramineae), which takes a crucial role in the stable crop population in Asia, resulted in the isolation of a new lignan, oryzativol C ( 1 ), as a minor component. The chemical structure of compound 1 was unambiguously confirmed using spectroscopic evidence (including 1D‐ and 2D‐NMR data), HR‐ESI‐MS, and CD data analysis. Considering the traditional medicinal efficacy of O. sativa and its importance as a food crop, compound 1 was evaluated for effects on breast cancer cell lines (MDA‐MB‐231) and on glucose‐stimulated insulin secretion in an INS‐1 pancreatic β‐cell line. Compound 1 showed mild cytotoxicity toward the MDA‐MB‐231. Furthermore, compound 1 stimulated insulin secretion in INS‐1 pancreatic β‐cells without inducing cytotoxicity. These results indicate that compound 1 is an active ingredient of O. sativa that offers health benefits including inhibition of breast cancer cell proliferation and hyperglycemia control.