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Three New Monoterpenoid Indole Alkaloids from Ervatamia pandacaqui
Author(s) -
Zhang Jian,
Ao YunLin,
Yao Nan,
Bai WenXin,
Fan ChunLin,
Ye WenCai,
Zhang XiaoQi
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800268
Subject(s) - chemistry , indole test , cytotoxicity , hydrolysis , stereochemistry , sugar , apocynaceae , organic chemistry , biochemistry , botany , in vitro , biology
Three new monoterpenoid indole alkaloids, ervapandine A ( 1 ), (3 R )‐hydroxyibogaine ( 3 ), 12‐hydroxyakuammicine N (4)‐oxide ( 6 ), along with four known ones, were isolated from the twigs and leaves of Ervatamia pandacaqui . The structures of the new alkaloids were elucidated by spectroscopic methods and sugar hydrolysis experiment. All of the compounds were evaluated for their cytotoxicity against three human cell lines. Compound 7 showed moderate cytotoxic activity.