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Antinociceptive Activity of Phloroglucinol Derivatives Isolated from Southern Brazilian Hypericum Species
Author(s) -
Bridi Henrique,
Dischkaln Stolz Eveline,
Maikon Corrêa de Barros Francisco,
Elingson da Silva Costa Bianca,
Guerini Letícia,
Maris Kuze Rates Stela,
Lino von Poser Gilsane
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800266
Subject(s) - phloroglucinol , chemistry , hypericum , stereochemistry , motor impairment , nociception , traditional medicine , biochemistry , organic chemistry , receptor , medicine , physical medicine and rehabilitation
The south Brazilian Hypericum species have revealed the presence of a series of biologically active phloroglucinol derivatives. In this study, a mixture of japonicine A and an isomer with an unreported structure, named japonicine E, was isolated from the roots of H. polyanthemum . Additionally, uliginosin A from H. myrianthum , isouliginosin B from H. polyanthemum , hyperbrasilol B and isohyperbrasilol B from H. caprifoliatum and cariphenone A from H. carinatum were also isolated. The structures were elucidated using 1D‐ and 2D‐NMR experiments and by comparison with previously reported data. The compounds japonicines A/E, uliginosin A, isouliginosin B, hyperbrasilol B and cariphenone A exhibited antinociceptive activity in the mice hot‐plate test and did not induce motor impairment in the rotarod apparatus.