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Chemical Constituents from Chloranthus anhuiensis and Their Cytotoxic Activities
Author(s) -
Zhu HuiLin,
Qu Wei,
Zhang Jie,
Guo ErYan,
Du Tao,
Liu WenYuan,
Cao WenYuan,
Feng Feng,
Xu Jian
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800249
Subject(s) - chemistry , methylenedioxy , stereochemistry , cytotoxic t cell , benzene , benzene derivatives , circular dichroism , alkoxy group , organic chemistry , chemical synthesis , biochemistry , in vitro , alkyl
Three hiherto unknown phenylpropanoid compounds, namely (7 S ,8 R )‐1‐(1‐ethoxy‐2‐hydroxypropyl)‐2‐methoxy‐3,4‐(methylenedioxy)benzene ( 1 ), (7 S ,8 S )‐1‐(1‐ethoxy‐2‐hydroxypropyl)‐2‐methoxy‐3,4‐(methylenedioxy)benzene ( 2 ), and (7 S ,8 R )‐1‐(1‐methoxy‐2‐hydroxypropyl)‐2‐methoxy‐3,4‐(methylenedioxy)benzene ( 3 ), along with 12 known compounds ( 4 – 15 ) were obtained from the extract of whole plant of Chloranthus anhuiensis . Among them, 7 and 13 were obtained from nature for the first time. The structures of these natural compounds were characterized by extensive spectroscopic analysis and calculated electronic circular dichroism ( ECD ) data. Furthermore, their cytotoxic and neuroprotective activities were evaluated using MDA ‐ MB ‐231, 4T1, HepG2, and PC 12 cell lines. Compounds 8 and 13 exhibited moderate cytotoxic activities against MDA ‐ MB ‐231 cell line with the IC 50 values of 39.7 and 25.8 μ m , respectively. And all the isolated compounds have no neuroprotective activities.
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