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Synthesis, Biological Evaluation, and Molecular Docking of Novel Thiazoles and [1,3,4]Thiadiazoles Incorporating Sulfonamide Group as DHFR Inhibitors
Author(s) -
Riyadh Sayed M.,
ElMotairi Shojaa A.,
Ahmed Hany E. A.,
Khalil Khaled D.,
Habib ELSayed E.
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800231
Subject(s) - thiadiazoles , chemistry , sulfonamide , docking (animal) , stereochemistry , antimicrobial , combinatorial chemistry , potency , halide , medicinal chemistry , biochemistry , organic chemistry , in vitro , medicine , nursing
2‐(1‐{4‐[(4‐Methylphenyl)sulfonamido]phenyl}ethylidene)thiosemicarbazide ( 3 ) was exploited as a starting material for the synthesis of two novel series of 5‐arylazo‐2‐hydrazonothiazoles 6a – 6j and 2‐hydrazono[1,3,4]thiadiazoles 10a – 10d , incorporating sulfonamide group, through its reactions with appropriate hydrazonoyl halides. The structures of the newly synthesized products were confirmed by spectral and elemental analyses. Also, the antimicrobial, anticancer, and DHFR inhibition potency for two series of thiazoles and [1,3,4]thiadiazoles were evaluated and explained by molecular docking studies and SAR analysis.