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HIV ‐1 Entry Inhibitors: A Review of Experimental and Computational Studies
Author(s) -
Mostashari Rad Tahereh,
Saghaie Lotfollah,
Fassihi Afshin
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800159
Subject(s) - viral entry , human immunodeficiency virus (hiv) , intracellular , receptor , viral life cycle , viral replication , chemistry , virus , cell , small molecule , microbiology and biotechnology , computational biology , entry inhibitor , virology , biology , biochemistry
The HIV ‐1 life cycle consists of different events, such as cell entry and fusion, virus replication, assembly and release of the newly formed virions. The more logical way to inhibit HIV transmission among individuals is to inhibit its entry into the immune host cells rather than targeting the intracellular viral enzymes. Both viral and host cell surface receptors and co‐receptors are regarded as potential targets in anti‐ HIV ‐1 drug design process. Because of the importance of this topic it was decided to summarize recent reports on small‐molecule HIV ‐1 entry inhibitors that have not been considered in the latest released reviews. All the computational studies reported in the literature regarding HIV ‐1 entry inhibitors since 2014 was also considered in this review.