Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (−)‐Borneol from  Abies sibirica  and (+)‐Camphor | Zendy

Sokolova Anastasiya S. | Zendy; Yarovaya Olga I. | Zendy; Bormotov Nikolay I. | Zendy; Shishkina Larisa N. | Zendy; Salakhutdinov Nariman F. | Zendy

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Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (−)‐Borneol from Abies sibirica and (+)‐Camphor

Author(s) -

Sokolova Anastasiya S.,

Yarovaya Olga I.,

Bormotov Nikolay I.,

Shishkina Larisa N.,

Salakhutdinov Nariman F.

Publication year - 2018

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.201800153

Subject(s) - chemistry , morpholine , camphor , heptane , vaccinia , cytotoxicity , bioassay , amide , stereochemistry , alkyne , virus , inhibitory postsynaptic potential , in vitro , combinatorial chemistry , organic chemistry , biochemistry , virology , catalysis , genetics , biology , gene , recombinant dna , neuroscience

A series of the bornyl ester/amide derivatives with N‐containing heterocycles were designed and synthesized as vaccinia virus ( VV ) inhibitors. Bioassay results showed that among the designed compounds, derivatives 6 , 13 , 14 , 34 , 36 and 37 showed the best inhibitory activity against VV with the IC 50 values of 12.9, 17.9, 3.4, 2.5, 12.5 and 7.5 μ m , respectively, and good cytotoxicity. The primary structure–activity relationship ( SAR ) study suggested that the combination of a saturated N‐heterocycle, such as morpholine or 4‐methylpiperidine, and a 1,7,7‐trimethylbicyclo[2.2.1]heptane scaffold was favorable for antiviral activity.

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