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Four Natural Compounds Separated from Folium Isatidis: Crystal Structures and Antibacterial Activity
Author(s) -
Liao BeiLing,
Pan YuJie,
Zhang Wei,
Pan LiWei
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800152
Subject(s) - chemistry , antibacterial activity , carboxylate , bacillus subtilis , steric effects , escherichia coli , stereochemistry , quinazolinone , bacteria , biochemistry , genetics , gene , biology
Four natural compounds were obtained by concentrating, separating and purifying from the Folium isatidis. These natural compounds have been characterized by elemental analysis, IR spectrum, NMR and single‐crystal X‐ray diffraction analysis. The results show that these natural compounds are 4(3 H )‐quinazolinone ( I ), 2,4(1 H ,3 H )‐quinazolinedione ( II ), methyl 3,4‐dihydro‐4‐oxoquinazoline‐2‐carboxylate ( III ) and ethyl 3,4‐dihydro‐4‐oxoquinazoline‐2‐carboxylate ( IV ). The antibacterial activity experiment showed that I and II had better activity against Staphylococcus aureus , Escherichia coli , Bacillus subtilis and Salmonella than III , IV and other multiple components, because III and IV have long branches and steric hindrance effect. Compounds I and II have planar structure, which can more easily combine with these bacteria and kill them. The above results have good guiding significance for studying the antibacterial activity for single components or mixtures from natural origin.