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Four New Diterpenoid Alkaloids from the Roots of Aconitum carmichaelii
Author(s) -
Li Yu,
Gao Feng,
Zhang JiFa,
Zhou XianLi
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800147
Subject(s) - terpenoid , ranunculaceae , chemistry , aconitum , alkaloid , cancer cell lines , stereochemistry , traditional medicine , botany , cancer , cancer cell , biology , medicine , genetics
Aconitum carmichaelii Debeaux is a widely used traditional Chinese medicine and an important source of clinical drugs, of which the parent and lateral roots are known as ‘Chuanwu’ and ‘Fuzi’, respectively. Four new C 19 ‐diterpenoid alkaloids, carmichasines A – D ( 1 – 4 ), were isolated from the roots of Aconitum carmichaelii , together with twelve known compounds ( 5 – 16 ). Their structures were elucidated via spectroscopic analyses, including HR ‐ ESI ‐ MS , IR , and NMR . Carmichasine A ( 1 ) is the first natural C 19 ‐diterpenoid alkaloid possessing a cyano group. Most of the diterpenoid alkaloids isolated were C 19 ‐category, which might provide further clues for understanding the chemotaxonomic significance of this plant. The cytotoxicity of the new compounds was also investigated against several human cancer cell lines, including MCF ‐7, HCT 116, A549, and 786‐0, and none of them showed considerable cytotoxic activity.