Premium
Hypofolins A – L, ent ‐Labdane Diterpenoids from the Roots of Hypoestes phyllostachya ‘Pink Splash’
Author(s) -
Cheng Bin,
Ding LinFen,
Yan Tong,
Xie ZhangQiao,
Zhang Zhijun,
Song LiuDong,
Wu XingDe,
Zhao QinShi
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800124
Subject(s) - labdane , chemistry , diterpene , stereochemistry , splash , butenolide , absolute configuration , ketone , organic chemistry , physics , meteorology
Twelve new ent ‐labdane diterpenoids, hypofolins A – F ( 1 – 6 ) and hypofolins G – L ( 7a / 7b , 8a / 8b , and 9a / 9b ), were isolated from the roots of Hypoestes phyllostachya ‘Pink Splash’. Their structures were elucidated by extensive 1D‐ and 2D‐ NMR spectroscopic and HR ‐ MS data. The absolute configurations of 1 , 2 , 5 , and 7a / 7b were determined by single crystal X‐ray diffraction and ECD analysis, as well as chemical transformations. Compounds 7a / 7b , 8a / 8b , and 9a / 9b were isolated as three pairs of interconverting mixture of two isomers between ketone and hemiketal types. Compound 1 showed weak cytotoxicity against SMMC ‐7721 cell line with IC 50 value of 31.40 μ m .