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Bioassay‐Guided Isolation of Antifungal Compounds from Disporopsis aspersa ( Hua ) Engl . ex Diels against Pseudoperonospora cubensis and Phytophthora infestans
Author(s) -
Zhu Feng,
Yuan Chengshan,
Gang Fangli,
Yang Chaofu,
Wu Wenjun,
Zhang Jiwen
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800090
Subject(s) - pseudoperonospora cubensis , downy mildew , phytophthora infestans , fungicide , bioassay , pyrimethanil , chemistry , plasmopara viticola , horticulture , biology , botany , blight , genetics
Oomycetes are one type of the most highly destructive of the diseases that cause damage to some important crop plants, such as potato late blight, cucumber downy mildew, and grape downy mildew. As main approach of the ongoing search for new botanical fungicide from plant, the secondary metabolites of D . aspersa were investigated. Through efficient bioassay‐guided isolation, two new ( 1 and 2 ) and 12 known compounds ( 3 – 14 ) were isolated, and their structures were determined via extensive NMR , HR ‐ ESI ‐ MS , and IR . They were isolated from this genus for the first time except for compounds 11 and 12 . The biological properties of 1 – 14 were evaluated against Pseudoperonospora cubensis and Phytophthora infestans . Compounds 1 – 8 showed potent antifungal activity in vitro . Additionally, compound 3 has preferable control effect on cucumber downy mildew, showing dual effect of protection and treatment in vivo .