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Synthesis and Antimicrobial Study of Novel 1‐Benzylated Water‐Soluble Isatin‐3‐hydrazones
Author(s) -
Bogdanov Andrei V.,
Zaripova Ilyuza F.,
Voloshina Alexandra D.,
Sapunova Anastasia S.,
Kulik Natalia V.,
Voronina Julia K.,
Mironov Vladimir F.
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800088
Subject(s) - isatin , chemistry , bacillus cereus , antimicrobial , reagent , ammonium acetate , yield (engineering) , staphylococcus aureus , ammonium , organic chemistry , combinatorial chemistry , bacteria , genetics , high performance liquid chromatography , materials science , metallurgy , biology
A high‐yield synthesis of some novel isatin‐3‐acylhydrazones on the base of 5‐ethylisatin derivatives and Girard's reagent T is described. Antimicrobial activity preliminary SAR study of both 1‐benzylated isatins and water‐soluble hydrazones was established. The most active against Staphylococcus aureus and Bacillus cereus are ammonium salts bearing 3,4‐dichloro‐ or 4‐ CF 3 substituents in benzyl fragment.