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Vibsane‐Type Diterpenoids from Viburnum odoratissimum and Their Cytotoxic and HSP 90 Inhibitory Activities
Author(s) -
Zhu QinFeng,
Qi YanYan,
Zhang ZhiJun,
Fan Min,
Bi Ran,
Su Jia,
Wu XingDe,
Shao LiDong,
Zhao QinShi
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800049
Subject(s) - chemistry , cytotoxicity , derivatization , stereochemistry , cytotoxic t cell , biochemistry , in vitro , mass spectrometry , chromatography
Four new vibsane‐type diterpenoids, vibsanol I ( 1 ), 15‐hydroperoxyvibsanol A ( 2 ), 14‐hydroperoxyvibsanol B ( 3 ), 15‐ O ‐methylvibsanin U ( 4 ), and a new natural product, 5,6‐dihydrovibsanin B ( 5 ), as well as six known analogues, were isolated from the twigs and leaves of Viburnum odoratissimum . Their structures were elucidated by spectroscopic analyses and chemical derivatization method. All compounds showed different levels of cytotoxicity against five cell lines ( HL ‐60, A‐549, SMMC ‐7721, MCF ‐7, and SW 480). Remarkably, 14,18‐ O ‐diacetyl‐15‐ O ‐methylvibsanin U ( 4a ) showed significant cytotoxicity against HL ‐60, A‐549, SMMC ‐7721, MCF ‐7, and SW 480, with IC 50 values of 0.15 ± 0.01, 0.69 ± 0.01, 0.41 ± 0.02, 0.75 ± 0.03, and 0.48 ± 0.03 μ m , respectively. In addition, vibsanin K ( 10 ) was identified as a HSP 90 inhibitor with an IC 50 value of 19.16 μ m .