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Iridoids from Pedicularis verticillata and Their Anti‐Complementary Activity
Author(s) -
Shao MingHui,
Dai Wei,
Yuan SiWen,
Lu Yan,
Chen DaoFeng,
Wang Qi
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800033
Subject(s) - chemistry , pyran , stereochemistry , iridoid , alkoxy group , in vitro , glycoside , biochemistry , organic chemistry , alkyl
Three new iridoids named as pediverticilatasin A – C ( 1 – 3 , resp.), together with five known iridoids ( 4 – 8 , resp.) were isolated from the whole plants of Pedicularis verticillata . The structures of three new compounds were identified as (1 S ,7 R )‐1‐ethoxy‐1,5,6,7‐tetrahydro‐7‐hydroxy‐7‐methylcyclopenta[ c ]pyran‐4(3 H )‐one ( 1 ), (1 S ,4a S ,7 R ,7a S )‐1‐ethoxy‐1,4a,5,6,7,7a‐hexahydro‐7‐hydroxy‐7‐methylcyclopenta[ c ]pyran‐4‐carboxylic acid ( 2 ), (1 S ,4a S ,7 R ,7a S )‐1‐ethoxy‐1,4a,5,6,7,7a‐hexahydro‐7‐hydroxy‐7‐methylcyclopenta[ c ]pyran‐4‐carbaldehyde ( 3 ). Their structures were elucidated on the basis of spectroscopic methods and compared with the NMR spectra data in the literature. All compounds were evaluated for their anti‐complementary activity on the classical pathway of the complement system in vitro . Among which, compounds 1 , 3 , and 6 exhibited anti‐complementary effects with CH 50 values ranging from 0.43 to 1.72 m m , which are plausible candidates for developing potent anti‐complementary agents.