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Evaluation of In Vitro α ‐Amylase and α ‐Glucosidase Inhibitory Potentials of 14 Medicinal Plants Constituted in Thai Folk Antidiabetic Formularies
Author(s) -
Somtimuang Chonlatid,
Olatunji Opeyemi Joshua,
Ovatlarnporn Chitchamai
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800025
Subject(s) - traditional medicine , chemistry , amylase , acarbose , inhibitory postsynaptic potential , diabetes mellitus , in vitro , enzyme , medicinal plants , alpha amylase , glycoside , biochemistry , biology , medicine , stereochemistry , endocrinology , neuroscience
The sporadic increase in the occurrence and prevalence of diabetes mellitus have compelled and vigorous search for alternative anti‐diabetic therapeutic approach from medicinal plants and its bioactive. One of the major approach employed is the reduction of gastrointestinal glucose levels through the inhibition of carbohydrate digesting enzymes notably α ‐amylase and α ‐glucosidase. In this study, the ethanol extracts of 14 selected plants from Mor Porn's recipe were screened for their α ‐amylase and α ‐glucosidase inhibitory activity. The ethanolic extract from the stem of Vitex glabrata displayed the highest percentage inhibitory activity of 84.98 ± 0.59 and 84.71 ± 1.51 against α ‐glucosidase and α ‐amylase enzymes, respectively. Chemical investigation of the active extract of V. glabrata indicated that pentacyclic triterpenes were the major compounds responsible for the activity. The result obtained from this study suggests the potential use of V. glabrata as an alternative natural source for the treatment of diabetes mellitus.