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Salvisertin A, a New Hexacyclic Triterpenoid, and Other Bioactive Terpenes from Salvia deserta Root
Author(s) -
Wang YinRu,
Yu Yun,
Li ShuMing,
Liu Wei,
Li Wei,
MorrisNatschke Susan L.,
Goto Masuo,
Lee KuoHsiung,
Huang XueFeng
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800019
Subject(s) - sulforhodamine b , terpene , chemistry , triterpenoid , potency , bioassay , stereochemistry , salvia , terpenoid , cytotoxicity , traditional medicine , botany , biochemistry , in vitro , biology , medicine , genetics
Using various chromatographic methods, a new hexacyclic triterpenoid, 2 β ,3 β ,24 β ‐trihydroxy‐12,13‐cyclotaraxer‐l4‐en‐28oic acid ( 1 ), together with ten known compounds, 2 α ,3 α ,23‐trihydroxyurs‐12,20(30)‐dien‐28oic acid ( 2 ), 6,7‐dehydroroyleanone ( 3 ), horminone ( 4 ), 7‐ O ‐methylhorminone ( 5 ), sugiol ( 6 ), demethylcryptojaponol ( 7 ), 14‐deoxycoleon U ( 8 ), 5,6‐didehydro‐7‐hydroxy‐taxodone ( 9 ), ferruginol ( 10 ), and dichroanone ( 11 ), were isolated from the roots of Salvia deserta . Their structures were identified on the basis of spectroscopic analysis and comparison with the reported data. The individual compounds ( 1 , 3 – 8 ) were screened for cytotoxic activity, using the sulforhodamine B bioassay ( SRB ) method. As the results, Compounds 3 , 5 , and 8 showed cytotoxic potency against A549, MDA ‐ MB ‐231, KB , KB ‐ VIN , and MCF 7 cell lines with IC 50 values ranging from 6.5 to 10.2 μ m .