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Tyrosinase Inhibitors from the Aerial Parts of Wulfenia carinthiaca Jacq.
Author(s) -
Mutschlechner Benjamin,
Rainer Bettina,
Schwaiger Stefan,
Stuppner Hermann
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201800014
Subject(s) - phenylethanoid , chemistry , plantaginaceae , iridoid , glycoside , tyrosinase , stereochemistry , rhodiola , traditional medicine , biochemistry , botany , salidroside , chromatography , biology , enzyme , medicine
Activity guided isolation of a Me OH extract of the aerial plant parts of Wulfenia carinthiaca Jacq . (Plantaginaceae), using a mushroom tyrosinase assay, resulted in the isolation of five phenylethanoid glucosides and four iridoid glycosides. Two of them, 2′‐ O ‐acetylisoplantamajoside and 2′,6″‐ O ‐diacetylisoplantamajoside, represent new natural products. Evaluation of the inhibitory activity of all isolated compounds revealed that the observed activity is not related to the isolated phenylethanoid glycosides but mainly due to the presence of the iridoid glycoside globularin ( IC 50 41.94 μ m ; CI 95% ± 16.61/11.89 μ m ). Interestingly, structurally close related compounds (globularicisin, baldaccioside, and isoscrophularioside) showed no or only a weak tyrosinase inhibitory activity.