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Triterpenes and Meroterpenes with Neuroprotective Effects from Ganoderma leucocontextum
Author(s) -
Chen Hongyu,
Zhang Jinjin,
Ren Jinwei,
Wang Wenzhao,
Xiong Weiping,
Zhang Yaodong,
Bao Li,
Liu Hongwei
Publication year - 2018
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201700567
Subject(s) - lanostane , chemistry , mushroom , neuroprotection , terpene , stereochemistry , ganoderma , neurite , traditional medicine , medicinal fungi , biochemistry , food science , pharmacology , ganoderma lucidum , triterpene , polysaccharide , biology , medicine , alternative medicine , pathology , in vitro
Ganoderma leucocontextum is a well‐known medicinal mushroom cultivated in the Tibet Plateau of China. Chemistry investigation on the fruiting bodies of this mushroom resulted in the isolation of sixteen secondary metabolites including three new lanostane triterpenes, ganoleucoins Q – S ( 1 – 3 ), as well as thirteen known compounds ( 4 – 16 ). The structures of compounds 1 – 3 were determined by NMR , MS , CD spectral analysis, and chemical derivation method. The neuroprotective effects of compounds 1 – 16 were tested on PC 12 cells. Compounds 1 and 2 showed protective effects against the H 2 O 2 induced damage with the survival rate of 83.19 ± 0.92%, 73.37 ± 1.25% at the concentration of 200 μ m , respectively. Meanwhile, compounds 1 and 2 induced neurite outgrowth at 50 – 200 μ m . The results from this study suggested that G. leucocontextum and its metabolites may be potential functional food ingredients for the prevention of neurodegenerative diseases.